Testosterone Enanthate is probably the most popular Test ester out there. There’s no way you’ve missed it in any way if you have at least some experience.  This article brings up the basics, primarily for those who buy Testosterone Enanthate for the very first time and just start their path in the steroids world.  Testosterone with No Enanthate Ester: Basics What’s the big deal with Testosterone? It’s the primary male sex hormone, an androgen.  It’s responsible (fully or partly) for ALL anabolic properties of your existence [1]. Think muscle gains and faster protein synthesis. Produced mainly by the Leydig cells in the testes in men, it doesn’t just stop there.  It’s a vital product of peripheral metabolism, essential for both men and women, in different doses. Testosterone’s Biological Activity Testosterone itself? Not that biologically active. Surprising, right? It doesn’t easily bind with androgen receptors.  Think of it as a pre-hormone. Before it can flex its muscle on target cell receptors, it needs a little makeover by an enzyme called 5α-reductase. Enter dihydrotestosterone – the upgraded, biologically active version of testosterone. Testosterone Enanthate Basics Testosterone Enanthate is basically a fancy long form of natural testosterone. The Enanthate ester tail makes Testosterone (that naturally leaves your body in 4,5 hours) a long-acting steroid. You get over a week of effects from one injection.  Stability and consistency is more important than the onset speed when it comes to muscle growth. The downside is, depending on your metabolism and hormonal background, it’s not a quick fix: expect an average action time of about 2 weeks before you see its effects [2]. Enanthate: Profile Here’s the lowdown: Anabolic Activity: 100% of Testosterone, because it’s the benchmark for all steroids. Androgenic Activity: Again, 100%.  Aromatization: High. This is the process where testosterone turns into estrogen. Because of this, there’s a need for anti-estrogens aka AI’s. No one wants estrogenic  side effects [3]. HPTA (Hypothalamus-Pituitary-Testes Axis) Suppression: It’s pronounced. This means natural testosterone production can take a hit, and will take a hit, just by design. This is why you need PCT. Liver Toxicity: Good news? It’s nonexistent. Your liver gives this one a thumbs up. Method of Administration: Injections. Not a pill or a patch (unless we’re talking TRT doses). Duration of Action: About 10,5 days. Detection Time: 3 months. Doping tests can spot it for a while. In a nutshell: If you’re thinking about Testosterone Enanthate, know what you’re getting into. It’s powerful, long-lasting, and not without its nuances. As always, knowledge is power. Test E’s Effects and Impact on the Body Good: Muscle Growth & Pumps One major perk of Testosterone Enanthate? It seriously amps up both muscle mass and strength. This is why weightlifters and powerlifters swear by it. And for those chasing that “pumped” look after a workout, it delivers as well, well beyond any natty level. Bad: Water Retention Alongside its anabolic (muscle-building) effects, there’s a strong androgenic (related to male traits) kick. A quick weight gain is mostly due to water retention, thanks to sodium holding and estrogenic action [4]. Good: Recovery Boost This isn’t just about muscle. Testosterone Enanthate jumpstarts the body’s regeneration processes. You’ll likely feel a spike in overall energy, a boosted motivation to train, and it even helps in warding off overtraining. Bonus part: it also ramps up the oxygen capacity of your blood, so you can work out longer [5]. Testosterone Enanthate does a lot more than just bulk you up. From muscle gains, improved strength, to better joint health and faster recovery, it’s a multifaceted tool. Testosterone Enanthate Cycle The anabolic effect of Testosterone Enanthate directly relates to the dosage: Recommended dose: It’s between 250-500 mg weekly; Administration: Once a week, Ideally, in the buttocks; How long should a Testosterone Enanthate cycle last? Aim for at least 8 weeks, wrapping it up by gradually tapering the dose over 1-2 weeks; Side Effects Management To steer clear of adverse effects, introduce AIs into your regimen starting from week 2 or 3, as detailed in related articles: AIs on cycle; Guide to PCT. Here’s we’ll just cover the basics: HCG Going above 500 mg or stretching your cycle beyond 8 weeks? It’s time for gonadotropin (HCG). Inject 500-1000 IU weekly, ideally between Testosterone Enanthate shots. AI’s Take over 250 mg or know that you’re a heavy aromatizer? You need Arimidex, Aromasin, or Femara (we suggest Aromasin as a milder AI option if you’re a beginner). PCT Once your Enanthate cycle is over, introduce Nolvadex in mild doses of 10-20mg ED for 3-4 weeks. You need it to restore your natural Testosterone production and feel OK while it builds up. Best Stacks & Cycles for Test E If you’re aiming to pack on muscle, Testosterone Enanthate pairs well with several other agents. Think Deca Durabolin, Dianabol (oral), Trenbolone (mild doses, injectable), and Anadrol (as an alternative to Dianabol). Here’s a sample combo for you: 200 mg of Deca weekly; 250 mg of Testosterone Enanthate weekly; 12 weeks. Mild, simple, not over-the-top, but it will show you how stacks work. Some other effective stacks could be: Testosterone Enanthate with EQ for lean muscle growth; Testosterone Enanthate with Primobolan for a balance between muscle gain and fat loss. Don’t forget: always use anti-estrogens and HCG with stacks to maintain hormonal balance. Want that chiseled look? Complement your cycle with Winstrol or Anavar at moderate doses. But if you’re looking for alternatives, consider these: Testosterone Enanthate with Clenbuterol for a potent cutting effect; Testosterone Enanthate with Masteron for both definition and lean muscle retention. Note that cutting is 90% diet and just 10 the right stack, so don’t expect any miracles to happen out of the blue if you have over 15% body fat. Do your research to find the combination that works best for your goals.  Final Word Test E is the cornerstone of about 80% of all cycles out there. You can, of course, consider its alternative, Test Cypionate, but the two are nearly identical in all aspects that matter.  Start low, ramp it up, see how it goes: there’s no better way to find your sweet spot with Testosterone than experimenting. Just stay reasonable, don’t abuse it, never skip Aromatase Inhibitors and PCT, and you’ll be good.  References The effect of short-term use of testosterone enanthate on muscular strength

Aromasin aka Exemestane is an essential medication for your cycle. It’s an aromatase inhibitor that will help you keep your Test high and your Estrogen low (because this is how you get gains). Here’s an in-depth look at the drug, its properties, uses, and potential side effects. Overview Drug class: Aromatase Inhibitor Ative: 24-30 hours Chemical type: Steroidal suicide aromatase inhibitor Why you need it: to prevent excessive conversion of Testosterone into Estradiol Aromasin and Estrogen Reduction Simply put, exemestane lowers estrogen production in the body.  To get more info on AI’s in general, read our guide to Aromatase Inhibitors and aromatising steroids. Here, we’ll focus on Aromasin alone. Originally, it’s a breast cancer treatment compound. Yet, in the fitness community, Aromasin’s properties offer several advantages: Estrogen Reduction Exemestane reportedly lowers estrogen by an average of 85% [1]. It helps in preventing estrogen-related side effects often caused by aromatizing steroids. Other Benefits Aromasin destroys aromatase, which lowers Test, and also raises testosterone levels [2]. At the same time, Aromasin might increase levels of insulin growth factor (IGF-1) [3]. The exact compound you get from HGH.  Aromasin Dosing and Usage Aromasin is one powerful drug, and you definitely don’t want to risk taking too much of it:  Recommended starting dosage: Begin with 12.5mg once or twice per week. Continue adjusting the dose upward accordingly until you reduce high E2 sides. Peak Concentration Exemestane reaches its highest levels in the blood 2 hours after taking a 25 mg pill [4]. This rapid onset is something you should factor in. It is notably shorter than that for non-steroidal inhibitors. Half-life The active life of Aromasin ranges between 24 and 30 hours. Taking one 25mg pill lowers estrogen in the body for a few days. The biggest drop is 2 to 3 days after taking the pill. This suppression persists for about 4 to 5 days. Effective Dosing Research has shown that 25 mg Is more than enough. Using only 25 milligrams of Exemestane works just as well as 50 milligrams. It helps lower estrogen, boost testosterone, and increase IGF levels.  No need for higher doses: It’s unnecessary to go higher than 25 mg ED. Achieving Steady Plasma Levels When deciding how much to take, remember that Aromasin needs about a week to work well in your body.  However, it’s not a real problem: just start Exemestane a week prior to the moment you really need it. Aromasin Toxicity and Side Effects Aromasin has no significant drug toxicity at doses up to 600 milligrams per day. Most people can handle it without problems. We don’t know the highest safe dose yet. While generally mild, the negative side effects related to Exemestane use may include: Gastrointestinal effects; Hot flashes; Nausea and fatigue; Erectile dysfunction, though relatively rare. In addition, it may or may not affect your lipids. The studies that we have are inconclusive and conflicting [5]. Still, consider it if you have reasons to be concerned about your lipid profile. Conclusion: A Relatively Safe Choice Aromasin is a safe aromatase inhibitor with mild side effects and high potency. But, it’s important to control your dosage. Low Estrogen has similar side effects as low Testosterone. Those are not the effects you need (including erection issues, mood swings, and limited performance). Don’t take more than you’re supposed to, find your sweet spot and maintain balance. Aromasin FAQ What does Aromasin do to men? Aromasin lowers estrogen levels in men and can increase testosterone levels. Bodybuilders and athletes often use it to control estrogen-related side effects. Does Aromasin permanently block estrogen? No, Aromasin does not permanently block estrogen. If you keep taking the medication, its effects will last. After you stop taking it, estrogen levels usually go back to normal. Is Aromasin better than Arimidex? Aromasin and Arimidex both work well to inhibit aromatase, so it’s not fair to compare them. Instead, we can say that Aromasin is definitely a safer choice than Arimidex. Does Aromasin lower estrogen? Yes, it’s the only function. Aromasin reduces estrogen by blocking the enzyme that makes it called aromatase. When blocked, aromatase can’t convert anything. And since Aromasin is a suicide inhibitor, each enzyme it contacts has no chances to perform its functions. Does Aromasin remove gyno? Aromasin can reduce gynecomastia by controlling estrogen, but it can’t cure existing gyno. Treatment for existing gyno often requires surgery or other medical interventions. Is Aromasin liver toxic? Aromasin is usually well-tolerated. It doesn’t usually cause serious liver problems at normal doses. Who should not take Aromasin? Those allergic to Exemestane or who have certain health conditions should avoid it. Also, people with Estrogen issues. Mostly, though, it’s OK for the majority of bodybuilders. Is Aromasin bad for your heart? We don’t know how Aromasin affects heart health due to conflicting research. Monitoring and consultation with your doc is a MUST if you have reasons to worry about your heart. Can Aromasin cause blood clots? There’s no strong evidence to suggest that Aromasin directly causes blood clots. Always discuss potential risks and side effects with your healthcare provider. References https://pubmed.ncbi.nlm.nih.gov/12186378/; https://pubmed.ncbi.nlm.nih.gov/14671195/; https://pubmed.ncbi.nlm.nih.gov/12926095/; https://pubmed.ncbi.nlm.nih.gov/12404296/; https://pubmed.ncbi.nlm.nih.gov/14760111/.

Arimidex, also known as anastrozole, is a medication primarily used in the treatment of breast cancer. However, it has also become a popular choice among bodybuilders as a means of controlling estrogen levels during anabolic androgenic steroid cycles. One important thing you should understand, though, is that Arimidex is by no means a PCT compound.   It’s an AI so it belongs ON cycle, not AFTER it. You’ll see it from the description of the compound yourself. What is Arimidex? By structure, Arimidex is a non-steroidal aromatase inhibitor, which means it works by blocking the enzyme aromatase from converting androgens into estrogen.  By reducing the amount of estrogen in the body, Arimidex can help prevent the negative side effects associated with high estrogen levels: Water retention; Gynecomastia; Fat gains; Mood swings; Depression; Anxiety; Low libido; Decreased sperm count; And many others. Bodybuilders often use Arimidex during AAS cycles to control estrogen levels and avoid these nasty sides. What is PCT and What if You Skip It? Post-cycle therapy is a period of 2 to 4 weeks, sometimes up to 10 weeks, after your anabolic steroid cycle, needed to restore the natural Testosterone production.  If you don’t go for a post-cycle therapy, it can lead to a number of negative consequences. We can name three main risks here: Risk #1 — Hormonal Imbalance One of the main concerns is that without PCT, the body may not be able to fully restore its natural hormone levels. This can result in a decrease in testosterone production, which will INEVITABLY lead to a loss of muscle mass and strength. Risk #2 — Shutdown Additionally, when you stop taking anabolic steroids, your body’s natural testosterone production may shut down, so you may experience symptoms like: Decreased libido; Fatigue; Depression; Muscle loss.  PCT is used to help the body recover its natural testosterone levels and avoid these negative side effects. It’s important to note that PCT use should be supervised by a doctor, and the use of anabolic steroids should be avoided without a prescription and guidance from a medical professional. How to Take Arimidex Right? It is typically used in a small dose during the cycle to prevent estrogen levels from rising too high. The typical protocol for Arimidex therapy is to start with a low dose of 0.5mg per day and adjust the dose as needed based on blood work and symptoms. So What are Arimidex PCT Alternatives?  Arimidex should not be a part of a post-cycle therapy (PCT) protocol because it is not necessary for restoring natural hormone levels after a cycle of anabolic steroids.  PCT typically involves the use of drugs like clomiphene citrate aka Clomid or tamoxifen citrate aka Nolvadex.  Nolvadex and Clomid help to stimulate the production of luteinizing hormone and follicle-stimulating hormone, which in turn can help to restore natural testosterone production.  Arimidex AND Nolvadex on PCT would be too much for your natural estrogen and would completely shut it down, turning your daily life into an endless set of miserable side effects.  Best AI Alternatives ON Cycle? While Arimidex is a popular choice among bodybuilders, there are also alternative options available.  Letrozole, also known as Femara, is another aromatase inhibitor that can be used in a similar manner. It’s a new compound, relatively, of course, and it’s believed to be more aggressive than other options.   Aromasin is one more aromatase inhibitor, though it’s slightly less powerful. It’s also capable of reducing the extra estrogen levels on cycle and also — should not be a part of your PCT.  References Aromatase inhibitors in men: effects and therapeutic options https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143915/  ARIMIDEX: a new oral, once-a-day aromatase inhibitor https://pubmed.ncbi.nlm.nih.gov/7626450/  Should bodybuilders be taking Arimidex? https://www.medicalnewstoday.com/articles/arimidex-bodybuilding

In case your main goal is burning fat, Clenbuterol is an obvious choice. However, you can get even more effects from it, and get an even leaner physique as a result, if you run it in a stack. Here’s how it works. Clenbuterol Mechanism of Action Clenbuterol is a non-steroidal beta-2 agonist. You’ve heard it a thousand times, but what does it actually mean? In simple terms:  Agonist is just a fancy way to say “activator”. Clen’s only function in the body (if we’re talking about fat loss) is to activate the beta-2 receptors. Beta-2 receptors are located all around your body, on top of cells in all sorts of tissues. When Clenbuterol “activates” these receptors, it triggers a series of chemical reactions inside the cell. These reactions increase the activity of an enzyme called “adenylate cyclase”, which in turn increases the production of a molecule called cyclic AMP (cAMP).  cAMP is what you really need: this molecule plays a crucial role in all metabolic processes in your body, such as regulating the breakdown of stored fat and the production of heat. The more cAMP you have — the faster your body destroys fat tissue. Of course, it’s not all that simple, but now you know the general concept of what exactly “beta-2 agonist” stands for and how these fat burners work. The problem with Clenbuterol Tolerance Why don’t we all take Clenbuterol all the time and never get fat? The problem is, tolerance is a thing.  Your beta-2 receptors get “tired” easily from Clen. When you keep them “activated” all the time, they get desensitized, and just stop reacting to Clen at all.  Your body can “react” to the same dose of Clenbuterol for just 2 weeks straight. Afterwards, it just stops working. And sure, 2 weeks is not enough to get the fat burning effect you expect from Clen in the first place.  There are 3 ways to “trick” tolerance: raise the dose, take pauses, and take Ketotifene.  Should you raise the dose of Clen? One possible solution is to increase the Clenbuterol dosage gradually. That’s what many athletes do:  Start with 20mcg ED; Get to 40mcg ED in 2-3 days; 60 by the end of the first week; And so on.  Is it something we recommend? No way. Those who can do it are either genetically “lucky” to have no adverse effects from Clenbuterol or just run bunk (aka empty and underdosed) Clen and start getting the effects in high doses only.  Keep in mind that Clenbuterol is one powerful compound, with all the elevated cAMP in your blood you can expect it to give you a ton of side effects:  Nausea; Drowsiness; Headaches and hot flashes; Disturbed sleep; Cramps and tremors; Sometimes — chest pain, vomiting, and extreme sweating.  All these side effects are dose-dependent. You get a rather low risk of experiencing them at a mild dose, but the more you take — the more dangerous it gets. Just take pauses? It’s an obvious, and a classic approach. If your beta-2 receptors can “react” to Clenbuterol for just 2 weeks straight — fine! get the best out of those 2 weeks and let them “rest” for some time, so they get the ability to react to Clen again.  2 weeks on — 2 weeks off is one of the most common ways for athletes to take Clenbuterol.  For 2 weeks, you run a mild dose of Clenbuterol. For weeks 3 and 4 you ride with no Clen, just cardio, drinking a lot of water, eating right, and so on. For weeks 5 and 6 you get Clen back. Your receptors are ready for it and you get another round of an increased metabolic rate.  Is it convenient, though? You’re pretty much wasting your time, lose fat slower than you could, and get less results in the end. How Ketotifen Helps Ketotifen is an antihistamine compound. In its original intended use, it’s supposed to help people with allergies. However, it does not one, but three things in the process: Blocks histamine (the substance that is released by the body in response to an allergen, the exact thing that causes those with pollen allergy start itching, crying, and swelling); Reduces the activity of certain immune cells; And increases the sensitivity of beta-2 receptors. The third part looks exactly like what you need with Clenbuterol, and that’s right: Ketotifene makes your beta-2 receptors more sensitive, so they need less Clenbuterol to trigger the production of cAMP and boost your weight loss. It’s like increasing the dose in terms of results, but instead — you make the same dose more effective.  Clenbuterol and Ketotifen Stack Results To sum it up, without Ketotifen, your only options to get the effects after 2 weeks are: Increase the dose — but get more negative side effects and put more pressure on your body; Take breaks — but get less notable results and waste your time, taking Clen just for 2 weeks at a time. With Ketotifen, you: Can effectively use Clenbuterol for 6 to 8 weeks straight, without raising the dosage; Get better results without wasting your time on breaks; Get more benefits with less dose-dependent side effects. if it sounds like a win-win — you’re absolutely right.  Consider the extra benefits as well: Both Ketotifen and Clenbuterol are Health Canada and FDA-approved; Ketotifen is not the most expensive thing on the market, you can get 100 tabs of 1mg for around 70-100$, which is enough for 2 full 8-week-long cycles; Ketotifen reduces Clenbuterol’s side effects, including tremor, headaches, and nausea; And finally, Ketotifen normalizes the heart rate that Ketotifen speeds up, so you get less cardiovascular risks.  Clen without ketotifen is one powerful, tried-and-true weight loss booster. However, WITH Ketotifen, Clen also gets significantly more effective and safer at the same time. Other Stack Options Yohimbine Yohimbine, made by processing the bark of the yohimbe tree. It works by blocking a type of receptor in your body called alpha-2 receptors, which are found in fat cells. When alpha-2 receptors are blocked by Yohimbine, it can lead to an increase in

What is aromatization? It’s a natural process that happens all the time in your body, when your aromatase enzymes convert testosterone into estrogen.  It’s important to understand that aromatization is NOT your enemy. It’s crucial to maintain a healthy estrogen level in the body. Yes, even though you are male, some female sex hormones, in minuscule amounts, are still necessary. What are aromatase enzymes? Aromatase enzymes are just proteins in your body that are built to perform this conversion. These enzymes are found in many tissues, including (and mostly in)  fat cells, skin, liver, and brain. Just in case you were curious, aromatization and aromatase are called this way because of the aromatic ring in their structure (a ring-shaped molecule with alternating double-bond atoms). Which steroids do aromatize? The full list In short, anything that is Testosterone or Testosterone-like can be turned into estrogen.  Here’s the list of the most popular aromatizing steroids that aromatize:  Testosterone Test obviously aromatizes, in all its forms, including esters, like Enanthate, Cypionate, Propionate, Decanoate and non-esterified versions (Testosterone Suspension, Testobase).  Dianabol Dbol DOES aromatize, because methandrostenolone is basically a modified testosterone molecule. Deca Durabolin and NPP Both Deca and NPP are Nandrolone-based, and both ARE aromatizing. You need to note that nandrolone aromatizes 5 times less effectively and twice as slow as Testosterone does, so we can say that Deca is MILDLY aromatizing. EQ Equipoise, aka Boldenone, is another example of a compound that can be a substrate for aromatase enzymes, though not really an effective one. It’s also mildly aromatizing, if aromatizing at all (depends on your individual response).  Which steroids do NOT aromatize? The full list Some compounds are either not built for aromatization from the start or were modified to avoid it.  Here’s a list of compounds that do NOT require aromatase inhibitors on cycle: Masteron It’s not just safe in terms of aromatization, it’s also a weak anti-estrogen itself. Masteron, however, still requires caution with dosing, it’s still not the safest compound available. Anavar Oxandrolone, aka Anavar, is a mild strength booster that’s based on DHT (aka dihydrotestosterone), not on Testosterone itself, so it can’t aromatize. Anadrol Anadrol is also DHT-based, so you don’t really need an AI with it. It’s still heavily estrogenic, though, so you have to be careful. Winstrol  Stanozolol (on the market as Winstrol) is made using a DHT molecule as a basis, so it’s also safe in terms of aromatization. It’s true for both oral and injectable Winstrol options. Primobolan Primo is the final DHT-based substance that can’t structurally be aromatized.  Trenbolone Even though Tren is made with Nandrolone as a basis, it does not aromatize at any significant rate because of the modified structure.  Specifically, it has a double bond at the 9th and 10th carbon atoms (in simple terms, the «binding» site for aromatase is removed, so it can’t even connect to the molecule, let alone convert it).  Turinabol Even though it’s derived from Testosterone, Turinabol is structurally modified with a so-called chloro group that resists the aromatization.  What is considered a normal aromatization? Just as we said earlier, aromatization itself is not a bad thing. It’s vital to keep your body healthy and functional. Unfortunately, it’s a strictly individual process, with some men being heavy aromatizers (aka they have a lot of aromatase enzymes and those are exceptionally active), and some being the opposite.  We can’t really measure aromatization rates once and for all. We CAN, however, measure the result of aromatization: estrogen.  Healthy estrogen level for men The only way to check it is by doing bloodworks. When you get your result, the estrogen will, most likely, be measured in picograms per milliliter (pg/mL).  Most likely, you won’t get an “Estrogen” graph in the results, since “Estrogen” is just a term used to describe a whole group of similar hormones: estradiol, estrone and estriol.  Estradiol, aka E2, is the one that you should be looking at:  Anything between 10 and 40 pg/mL is considered a normal level of E2 for a healthy male. Note that those figures are individual. Maybe your minimal comfortable level is at about 12.5 pg/mL, maybe you’ll feel OK with your E2 at 45 pg/mL. The best thing you can do here is just using the figures as a reference point and a signal to watch out for red flags — high and low estrogen side effects. SOme of them are really hard to miss. Low estrogen side effects: Fatigue and lethargy; Dry and less sensitive skin; Low libido and inability to get an erection; Depression, anxiety; Nervousness, aggression, irritability. High estrogen side effects: Inability to get an erection, low libido; Faster fat gains, water retention; Oily skin, acne, increased sweating; Disrupted sleep patterns, sleepiness or inability to fall asleep; Aggression, irritability, nervousness; Blood pressure issues, higher risk of heart disease; And finally, gynecomastia, aka male boobs. As you can see, both high and low Estrogen is bad. You need to keep it under full control, within the normal range.  Since aromatizing anabolic steroids are more likely to push you above the healthy limit, to keep E2 in the healthy frames, you need to lower it and decrease your aromatization rate.  And this is exactly what aromatase inhibitors do. What are aromatase inhibitors and when you need them?  You need AIs on cycle, alongside all the gear that you run, to keep E2 levels in check. Aromatase inhibitors are made to inhibit (deactivate) aromatase enzymes. Arimidex, Aromasin and Femara do it in 3 different ways with the same result — lower estrogen.  Note that you should be careful with ALL aromatase inhibitors, regardless of their mechanism of action, since all three are capable of completely destroying your E2 and practically replacing high estrogen side effects with low estrogen side effects.  Which AI to choose? In an extremely short and oversimplified description, you need: Arimidex — when your E2 is extremely high; Aromasin — for proactive on-cycle support and if your E2 is higher than normal, but not THAT high; Femara — only when you already have gynecomastia and other high estrogen side effects, since it’s the newest and the most powerful AI option. Each aromatase inhibitor requires individual approach and further research, if you

Elevated blood pressure is dubbed “the silent killer” for a reason. The last thing you need is putting excessive pressure on your cardiovascular system. Unfortunately, steroids do just that. How can you minimize the risks? How Steroids Affect Heart Health Anabolic steroids can make you massive and strong, though they have a crucial flaw: they’re not selective in their action. If you inject, say Trenbolone Enanthate, it will provide some effects — good and bad — all around your body.  The three main areas of extra concern are:  Blood pressure; Cholesterol; Heart hypertrophy. Blood pressure is perhaps the most dangerous one.  Steroids and Blood Pressure You can expect nearly all anabolic steroids to cause some elevation in blood pressure. All of them to a different extent, though. For example, Stanozolol is going to raise your BP just a little, Winstrol will push it significantly higher, and Testosterone Enanthate’s effects on BP are strictly dose-dependent.  Practically, symptoms of elevated blood pressure look like this, listed from mild to severe: Notable pulsation in your temples; Dizziness; Fatigue; Headaches; Occasional blurry vision; Nosebleeds; Chest pain; Arrhythmias.   Doses, cycle length, individual factors, pre-existing conditions, and about a dozen other aspects will define which of these you will experience.  How Steroids Affect BP? In extremely oversimplified versions, the three main ways the steroids in your cycle affect BP are:  Water Retention Gear (especially «wet» injectable bulkers like Testosterone) can cause water retention, you get more fluid running through your veins, and the blood pressure goes higher; Vasoconstriction (narrowing of the blood vessels) Your blood vessels literally get slightly narrower in diameter with AAS. Less space for all the blood to run through equals higher blood pressure. Increased RBC Production Anabolic steroids promote increased red blood cell count. Some AAS (“dry” orals more so) stimulate the production of a hormone called erythropoietin, which is responsible for the production of RBCs in the bone marrow.  While increasing RBC production may seem like a good thing, it can actually have negative effects on heart health. Along with a better pump, a more notable muscle oxygenation, better endurance and less fatigue from intensive workouts, you get — physically — more red blood cells in your blood, and higher blood pressure as a result. What Can You Do About It? So we have it clear, the gear you take is not particularly good for your blood pressure. What now? What exactly should you do to keep the issue under control?  We suggest this plan:  Eliminate the worst of the risks; Go for lifestyle adjustments; Monitor your heart closely; Minimize the peak damage on cycle with medications.  Here’s a step-by-step plan, an expanded version that (if you follow it) would make your cycle way safer in terms of cardiovascular issues.  Step 0: Make Sure You Actually Can Take Steroids It’s step zero for a reason: if you have pre existing heart conditions, you should NOT take steroids. Simple as that.   Steroids are EXTREMELY dangerous, if you have or had:  Heart valve disease; Aortic aneurysm; Aortic dissection; Cardiomyopathy; Pericarditis; Endocarditis; Myocarditis; Pulmonary hypertension; Stroke; Transient ischemic attack (TIA); Peripheral artery disease (PAD); Venous thromboembolism (VTE); Deep vein thrombosis (DVT); Pulmonary embolism (PE). That’s not an extensive list, since there are hundreds of heart health issues, and you actually  need a full-scale check-up, but you get the main point: if your heart is not OK — you’re not supposed to take steroids, orals or injectables, they possess a life threat for you.  Sorry, but it’s “better natty than dead”.  Step 1: Lifestyle Adjustments That’s where we get practical. If you plan on taking or already take anabolic steroids, you know that some extra pressure is coming for your cardiovascular system. Wouldn’t it be nice to remove some of the existing pressure from it first? Here’s a list of things you can do to get a natural “boost” in heart health:  Quit drinking (alcohol is bad for your heart, and you know it); Quit smoking (quite an obvious one); Lose weight (at least try to, fat tissue is notoriously bad for your heart and blood pressure); Lower stress (sounds simple, hard to implement, but if you at least try to eliminate some of the stress factors that cause spikes in BP — it would be nice); Stop eating junk food (trans fats affect your cholesterol, and cholesterol affects your heart health); Eat more healthy food (whole grains, fruits and veggies, low-fat dairy, you know the drill); Work on your sleep (if you have messed up sleep schedule, your heart is under extra pressure daily); Work out regularly (we assume you already know the benefits of physical activity and don’t skip your workouts). None of these things alone can significantly alter your heart health or make you “risk-proof” in terms of steroidal side effects on blood pressure. Implemented all together, though, these things would make a difference. Step 2: Monitoring It’s more of a check-box thing, not a practical step. What exactly can you do to make sure you know, at any given moment, how “good” or “bad” your heart is doing now?   Maybe it means buying a wrist monitor or a watch (though those are not always accurate); Or doing your research and buying a classic BP monitor and learning to use it properly; Maybe it’s talking to your doc about regular checkups and making appointments in advance, for more in-depth analysis; Something as basic as finding a clinic or a medical professional first to know where to go when in doubt; Or even googling normal BP for your age and finding the baseline, the resting norm for you.  Depending on your experience, you can take whatever steps necessary, mentioned here or the ones you come up with on your own. It’s not the exact steps that matter here, it’s the goal: You should be able to monitor your blood pressure when it’s necessary, accurately, with an ability to analyze it and say if it’s OK or not. Step 3: Have Medication On Hand If you make it to this step, you already know that you have no pre-existing BP issues, know that your lifestyle puts no extra pressure

Bromonordiazepam is a pharmaceutical drug belonging to the benzodiazepine family. In other words — yes, it’s yet another benzo sleeping pill. It is derived from the popular sedative and anxiolytic medication, Diazepam. The key difference with other benzos? In short, it’s milder than other comparable options.  Known for its calming and sedative properties, Bromonordiazepam is primarily prescribed for the treatment of anxiety, insomnia, and muscle spasms. The Benefits of Bromonordiazepam As you would expect from a benzo, its primary effect is calming your nervous system down and knocking you out to sleep. The full list of benefits is larger, though, and typically includes: Anxiety Relief Bromonordiazepam is highly effective in reducing symptoms of anxiety disorders. By targeting specific receptors in the brain, it helps alleviate feelings of worry, fear, and unease. Insomnia Treatment People with sleep disturbances or insomnia often find Bromonordiazepam beneficial. In fact, this is the primary use for the compound. Its sedative properties promote relaxation, making it easier to fall asleep and enjoy a restful night. Muscle Spasm Management Bromonordiazepam has additional muscle relaxant properties, making it a valuable treatment option for individuals suffering from all sorts of tension. It helps relieve discomfort and reduces muscle contractions. Seizure Control In some cases, Bromonordiazepam may be prescribed to manage seizures, especially in individuals with epilepsy. By stabilizing electrical activity in the brain, it can help prevent or reduce the severity of the disease.  The Mechanism of Action Bromonordiazepam works by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain. GABA acts as a natural tranquilizer, slowing down nerve cell activity and promoting relaxation.  We’ve got a more detailed description of the way GABA works in this guide on Lorazepam: all benzos are similar in their effects on this neurotransmitter. Bromonordiazepam Dosage Guidelines As usual, the recommended dosage of Bromonordiazepam may vary depending on factors such as your medical condition, age, and individual response to the medication. In general, the starting dosage of Bromonordiazepam is typically low to minimize the risk of adverse effects:  A common initial dosage is 1 tablet per day, taken orally.  However, it’s important to note that the specific dosage and frequency may be adjusted based on your individual needs and response to treatment. Administration and Timing — When to Take Bromonordiazepam? Bromonordiazepam typically starts to take effect within 30-60 minutes after ingestion. The peak effects are usually experienced around 3-4 hours after administration. The effects can last between 6-8 hours. It’s important to plan your activities accordingly, allowing sufficient time for rest and recovery if necessary. Don’t take the drug before driving, going to any important events, and so on: it’s called a sleeping pill for a reason. Precautions and Safety Guidelines Avoid alcohol consumption while taking Bromonordiazepam. Alcohol can enhance the sedative effects of the medication, leading to increased drowsiness and impaired coordination. It’s also not quite good for your brain. Never quit it cold turkey! Benzodiazepines like Bromonordiazepam should not be abruptly discontinued. A gradual schedule is crucial to minimize the risk of withdrawal symptoms. Potential Side Effects While Bromonordiazepam can be highly effective, it’s essential to be aware of potential side effects. Common adverse effects may include: Drowsiness; Dizziness; Impaired coordination; Confusion.  Also, some other medications or medical conditions may interact with Bromonordiazepam, leading to more adverse effects. Make sure it combines well with every other medication you may take. Gidazepam vs Phenazepam: Comparing Benzodiazepines Gidazepam is a benzodiazepine medication primarily used for its anxiolytic properties. It’s known for its relatively fast onset of action and intermediate duration of effect. Phenazepam shares a similar mechanism of action with Gidazepam, augmenting GABA’s inhibitory effects in the brain.  So, what’s the difference? There are two important aspects to consider, despite the compounds being relatively similar: Half-life: Gidazepam typically has a shorter duration of effect compared to Phenazepam; Potency: a lower dosage of Phenazepam may produce similar effects compared to a higher dosage of Gidazepam. So Bromonordiazepam, as a Diazepam derivative, is milder and faster than, say, Lorazepam, a typical benzodiazepine derivative, or 3-hydroxyphenazepam (a Phenazepam derivative). It’s definitely not THAT simple but you can give milder options a try before switching to more potent ones. 

Insomnia: a condition that can have detrimental effects on your overall well-being, affecting our productivity, mood, and (most importantly) your progress in the gym.    Zolpidem: a widely prescribed medication that helps with insomnia and other sleep-related issues.    Can you see how the two combine perfectly in a problem-solution way? Well, that’s probably why Zolpidem — aka Ambien — is considered the golden standard of sleeping pills. What is Zolpidem? The most important part? It’s a non-benzo medication. Zolpidem belongs to a class of drugs known as sedative-hypnotics. It is primarily prescribed to treat insomnia (aka difficulty falling asleep or staying asleep).    Zolpidem works by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain. More on GABA here in our Lorazepam guide, if you want to dive into the details.    What makes Zolpidem a little different from other options is that it has a wider range of applications. The Benefits and Sides of Zolpidem Naturally, the main role for Zolpidem has been a sleep aid for people suffering from insomnia. It helps to reduce the time needed to fall asleep and improves the quality and duration of sleep. It has other benefits as well:   Reduced unwanted awakenings: Zolpidem can significantly reduce the frequency of the times you wake up at night, by calming your nervous system down via the GABA effects; Improved daytime functioning: The better you sleep, the better you feel the next day — including increased focus, concentration, and productivity; Short-term effects: Zolpidem is generally prescribed for short-term use, typically no longer than 2 to 4 weeks. It’s more than enough to solve your sleep issues.    While Zolpidem is generally well-tolerated, it may cause some side effects in some users. The most common adverse things are:   Drowsiness or sedation during the day; A dry sensation in the mouth (staying hydrated and using sugar-free gum can help alleviate this discomfort); Bitter or metallic taste in the mouth after Zolpidem (resolves on its own); Headaches or dizziness (especially with doses on the higher end of the scale).   How to Say Whether Zolpidem is Safe for You Before starting Zolpidem, it is crucial to consider some precautions and discuss them with your doc. You SHOULD NOT take Zolpidem, if you have:   Liver or kidney disease; Respiratory disorders; History of substance abuse; Mood disorders or mental health conditions; Allergy to any of the compound’s components.   Obviously, if you’re a female athlete and you are pregnant, planning to become pregnant, or breastfeeding, Zolpidem is not the best thing for your health. Zolpidem Interactions One more thing to consider: you should not mix Zolpidem with medications that react with it in any adverse ways.    It applies to other sleeping pills and other drugs in the same category:   Benzodiazepines; Antidepressants; Antipsychotics; Muscle relaxants; Antihistamines.    Really talk to your doc if you have any of these officially prescribed and plan on introducing Zolpidem to the stack. Zopiclone vs Zolpidem We get it, they sound really alike. However, those are not just different trade names for the same medication. Zolpidem and Zopiclone are two different compounds.    Mechanism of action: Zolpidem specifically binds to a subtype of the GABA receptor; Onset: Zolpidem has a faster onset compared to Zopiclone; Half-life: Zopiclone has a longer half-life, allowing you to stay asleep for a longer period. Zolpidem, on the other hand, has a shorter half-life of just about 2 hours; Availability: Zolpidem is way, WAY more common. Zolpidem Dosage and Administration Guide  Zolpidem is available in 10 mg pills. The usual recommended dose is one 10mg tablet, taken just before bedtime. It typically takes about 1 hour for Zolpidem to start working and help you fall asleep.   The lower dose is often recommended for people over 65 years old or those with kidney or liver problems.  Zolpidem Administration  Follow the guidelines on the pack (or the ones above, same thing). There’s not much you can alter in this process, it’s pretty straight-forward:   You can take Zolpidem with or without food; Take Zolpidem on only 2 or 3 nights each week; Take it for 2 to 4 weeks before possibly stopping the treatment to avoid tolerance); Don’t drop Zolpidem out of the blue, tamper off gradually.   Oh, and if you forget to take your Zolpidem dose before bedtime, skip the missed dose and take the next scheduled dose at the usual time the following night. Don’t rush it. The Conclusion Zolpidem is just a little different from other benzodiazepines. Faster, more common, but ultimately — the same thing. That’s why it’s considered to be the benchmark for this class of compounds.    Still, though, most of the time it gets down to personal response to the drug, and there’s a pretty good chance Zolpidem will help when other medications have failed. It’s all individual — as always.  References Zolpidem: Efficacy and Side Effects for Insomnia https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567759/; Long-Term Treatment of Insomnia with Zolpidem: A Multicentre General Practitioner Study of 107 Patients https://journals.sagepub.com/doi/10.1177/030006059101900313; Role of Zolpidem in the Management of Insomnia https://onlinelibrary.wiley.com/doi/full/10.1111/j.1755-5949.2010.00158.x

When you think of benzodiazepines, 3-Hydroxyphenazepam is rarely the first option that comes to mind, However, it’s definitely one you should consider: in comparison with other benzos, 3-Hydroxyphenazepam works just as good, and sometimes — better than alternatives. What is 3-Hydroxyphenazepam At its core, 3-Hydroxyphenazepam is a potent compound that interacts with gamma-aminobutyric acid (GABA) receptors in the central nervous system.  The specific binding affinity of 3-Hydroxyphenazepam to GABA receptors sets it apart from other benzos. Its high potency allows for a lower dosage requirement, reducing the risk of side effects while still delivering the desired therapeutic effects.  Additionally, 3-Hydroxyphenazepam’s mechanism of action influences the natural sleep architecture. It’s a sleeping pill, after all! Unlike some sleep aids that disrupt the sleep cycle, this one preserves the integrity of the various sleep stages, ensuring a more restorative and refreshing night’s rest. How 3-Hydroxyphenazepam Works As a benzodiazepine, 3-Hydroxyphenazepam exerts its effects by enhancing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that functions as an inhibitory signal in the brain [1]. GABA acts by binding to specific receptors, which leads to a decrease in neuronal excitability and promotes relaxation. When 3-Hydroxyphenazepam enters the system, it binds to GABA receptors and enhances the inhibitory action of GABA. This results in a cascade of effects that lead to: Decrease in neuronal activity; Sedative effects; Anxiolytic effects; Muscle relaxation. In simple terms, by modulating GABA receptors, 3-Hydroxyphenazepam helps to calm the central nervous system and induce a state of tranquility. The two key aspects of 3-Hydroxyphenazepam’s mechanism of action are selectivity and high potency. Its specific binding affinity to certain GABA receptor subtypes distinguishes it from other benzodiazepines, allowing for a more focused and targeted effect. The Effects and Benefits One of the primary effects of the compound is… well, helping you to fall asleep faster. However, there’s more to it. Let’s take a closer look: Treatment of Insomnia Insomnia (aka difficulty falling asleep or staying asleep) can significantly impact your quality of life. 3-Hydroxyphenazepam offers a solution by soothing the central nervous system: 3-Hydroxyphenazepam helps you to fall asleep faster, stay asleep throughout the night, and wake up feeling refreshed. Anxiety Relief The compound’s anxiolytic properties make it an effective option for managing nervousness symptoms. By enhancing the inhibitory effects of GABA, it reduces anxiety, induces relaxation, and provides a notable sense of calm. Muscle Relaxation Muscle tension and stiffness often accompany anxiety and stress. You’re not just mentally not in a good place, your body suffers from it as well. 3-Hydroxyphenazepam’s muscle relaxant properties can help alleviate these symptoms, promoting physical relaxation and easing discomfort. The effect, again, comes from the interaction with GABA receptors. Preservation of Natural Sleep Architecture Unlike some sleep aids that disrupt the normal sleep cycle, 3-Hydroxyphenazepam preserves the natural architecture of sleep. It supports the various stages of sleep, including deep sleep and REM sleep, ensuring a more restorative rest. Disruptions or alterations in sleep architecture can lead to poor sleep quality, and selectivity here is actually a good thing. 3-Hydroxyphenazepam Dosage When it comes to using 3-Hydroxyphenazepam, dosage guidelines and the duration of use are essentially absent Online: the compound was never marketed. According to the community, though, it’s not that special:  The recommended dosage typically falls within the range of 1-2 mg per day. However, it is crucial to follow the specific recommendations and personal tolerance. Starting with the lowest effective dose is recommended. If necessary, the dosage can be gradually increased. For example, you can start week one with 1mg ED, and if it doesn’t work, up it to 2mg ED by week 2.  It is important not to exceed the recommended range, as higher doses may increase the risk of side effects and dependency.  The duration of use is typically limited to 2-4 weeks. Short-term use is generally recommended to avoid the potential for dependency and withdrawal symptoms.  The specific duration may vary depending on your individual circumstances and the nature of the sleep disorder treated.  3-Hydroxyphenazepam Side Effects You can expect them all, or expect none of them: it all depends on your personal response, your experience, and your ability to get the right dosage. Here’s the full list of things you should be prepared for nonetheless: Blurred vision; Disorientation; Dry mouth; Feeling lightheaded; Memory issues; Reduced strength in muscles; Nausea; Difficulty speaking clearly (high doses); Lack of balance or stability, especially in older individuals who may be at a higher risk of falls and injuries. It’s important to note that not everyone will experience these side effects, and the severity and occurrence of side effects may vary among individuals. If any of these side effects persist or become bothersome, it is advisable to consult a healthcare professional for further guidance. Final Word Sure, 3-Hydroxyphenazepam is a potent benzodiazepine that offers a range of therapeutic benefits for sleep disorders, anxiety, and all sorts of related conditions. However, it’s still better than other options: In comparison with Phenazepam, 3-Hydroxyphenazepam is a much milder, tame alternative. With its ability to preserve natural sleep architecture and alleviate symptoms associated with insomnia, anxiety disorders, and stress-related conditions, 3-Hydroxyphenazepam presents a valuable addition to the sleeping pills market. References https://link.springer.com/article/10.1007/BF02506568; https://pubmed.ncbi.nlm.nih.gov/33820715/; https://en.wikipedia.org/wiki/3-Hydroxyphenazepam.  

Zopiclone is one of the most potent compounds that can save the day and get your sleep routine back on track. We believe that the whole “addiction” mess is caused by the fact that the right and effective way to take Zopiclone and other benzos is overshadowed by the media drama.    You already know where to buy Zopiclone. Now, here’s how to take Zopiclone right to get your sleep schedule back together and avoid the risks. What is Zopiclone?  First of all, you should know it deeper than just sleeping pills or a Z-drug. Zopiclone belongs to a class of nonbenzodiazepines: these compounds affect the GABA neurotransmitters in your brain, but are different from the infamous «benzos» on a molecular level.    Does it make a lot of difference? Probably not. They’re still quite alike.  The Benefits of Zopiclone You can fall asleep in 15 minutes after going to bed. Guaranteed. That’s the primary goal of sleeping pills, and Zopiclone does its job flawlessly.   Zopiclone acts as a sedative: it intervenes in the way your brain transmits information to the central nervous system and slows the whole process down. You get:    Reduced anxiety; Less chaotic thoughts; Faster sleep onset (15 minutes or so); Better night time’s rest; The feeling of being well-rested the next morning.    In simple terms, you just RELAX: that’s what your body needs to safely and calmly fall asleep.  The Side Effects of Zopiclone If all the effects above sound familiar, you’re right: Zopiclone is largely similar to Lorazepam and other benzodiazepines.    The class of benzodiazepines is criticized for two things:  They can be addictive; They’re risky in terms of abuse and long-term consequences.  As you could read in our guide to Lorazepam use for anxiety and sleep issues treatment, those drugs work ONLY if you take them right. How to Take Zopiclone Right Step by step, here are some actions to take and questions to ask yourself, in order to safely approach this compound:  Step Zero: Make Sure You Can Take it The contraindications include:   Long-term use of any other benzodiazepine (or similar) compounds; Liver or kidney health issues, the chronic ones; Myasthenia; Sleep apnoea (seriously, this thing is more damaging to your heart than you might think, and Zopiclone will only make it worse); Mental health issues (like, serious ones); Addictions to alcohol or drugs.    Keep in mind that Zopiclone can cause dependency if you’re prone to it, and dependency leads to higher doses if you lose control. The right doses, though, are the key to successful Zopiclone treatment. Step One: Determine the Right Dose for Zopiclone All effects of Zopiclone are dose-dependent. However, all reasons for insomnia are different. Unless you talk about the whole thing with your doc and they prescribe you a well-determined dose, there’s no way to be sure. They’re most likely to prescribe you 3.75 for starters and raise it to 7.5 (the max dose legally) if half of it won’t work, though.    We suggest either talking to your doc or approaching Zopiclone in a low and slow manner:    Start with a mere 1/4th of the pill, about 2mg. It’s unlikely to do anything, but if you have intolerance or if you’re allergic to the compound (swelling, rashes are possible, rarely), you’ll have less problems the next day; If you’re fine with 1/4th — good for you! If not (and most likely, you’re not), go for the standard dose: 3.75mg, half a pill. It has higher chances to help; Still nothing? Ok, you’ve got to go higher: you can do it either gradually (3/4th of a pill) or jump right to the 7.5mg (one full tablet) right ahead.    7.5 mg is the highest you can go legally in most countries, Canada and the United States included. It’s a full-scale higher dose, so it’s almost guaranteed to work, unless you respond poorly to Zopiclone or have a tolerance to it.  Step 3: Determine the Treatment Length No, you can’t take Zopiclone every day forever. In fact, you can’t take it every day even for one week.  The optimal Zopiclone administration frequency is 3-4 times a week. The optimal treatment length is 2 to 4 weeks at a time.  Why You Should Be Careful With Zopiclone — Side Effects In case you start taking higher, unhealthy doses, way more than stated above or prescribed, the prolonged GABA enhancement will result in side effects:   Memory loss; Delirium; Irritation; Depression; Hallucinations and delusions; Speech impairment; Brain fog; Shakes and tremors; Severe anxiety.    It’s a sad list of effects, but that’s exactly what Zopiclone abuse does and what causes all the backlash in the media. If you’re in charge of your treatment and you know what you’re doing, when you need it, and how much, you can avoid them. Final Word Just as pretty much any other medicine, Zopiclone should be taken precisely in accordance with the prescription. Don’t take higher doses, don’t mix it with alcohol or drugs, and you’re good to go to enjoy falling asleep in minutes instead of hours.